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In general, adults with pemphigus and high TPMT activity are treated with normal doses of azathioprine (≥2.5 mg/kg/d). Patients with intermediate or low TPMT activity should receive a lower maintenance dose (≥0.5 to 1.5 mg/kg/d) depending on level of enzyme activity.
Diagnosis requires clinical presentation and histopathology that are consistent with pemphigus and either a positive direct immunofluorescence (DIF) microscopy result or serologic detection of autoantibodies against epithelial cell surface antigens.
Many people get better with treatment, although it may take years. Others need to take a lower dose of medication indefinitely to prevent their signs and symptoms from returning. And some people need treatment in a hospital — for example, to care for severe or infected sores. Request an appointment.
24 sie 2020 · The primary objective is the control and healing of the bullous skin and/or mucous lesions while minimizing, as much as possible, serious side-effects of treatment.
Key words: CD20 inhibitor; consensus; guidelines; pemphigus foliaceus; pemphigus vulgaris; treatment. Pemphigus encompasses a spectrum of rare mucocu-taneous bullous diseases that are autoimmune in origin. Because of the rarity of these diseases, it can take patients months before their pemphigus is diagnosed, during which time many are treated ...
Objectives: Review the pathophysiology of pemphigus foliaceus. Describe the typical presentation of pemphigus foliaceus. Outline the treatment options for pemphigus foliaceus. Explain the importance of improving care coordination amongst interprofessional team members to optimize outcomes for patients affected by pemphigus foliaceus.
15 maj 2020 · For initial treatment of moderate-to-severe pemphigus vulgaris/foliaceus, recommended treatment options now include rituximab (anti-CD20 antibody) in combination with corticosteroids (in the 2015 version, this immunosuppressant was recommended only for treatment-resistant disease).
