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26 sie 2021 · As a result, the presence of malignant ascites in advanced-stage ovarian cancer patients is associated with a poor prognosis, warranting the development of more effective treatments for the palliation of malignant ascites.
26 sie 2021 · Despite decades of evidence showing that the accumulation of peritoneal fluid portends the poorest outcomes for cancer patients, the role of malignant ascites in promoting metastasis and therapy resistance remains poorly understood. This review summarizes the current understanding of malignant ascites, with a focus on ovarian cancer.
Malignant ascites is one of the most common sequela of epithelial ovarian cancer. It causes significant symptoms and can have a detrimental impact on patient quality of life, especially in women with recurrent ovarian cancer.
The median survival following diagnosis of ascites was 5.7 months. Ovarian cancer favoured longer survival while low serum albumin, low serum protein and liver metastases adversely affected survival. The independent prognostic factors for survival were cancer type, liver metastases and serum albumin.
24 lip 2023 · Ovarian cancer (OC) is an aggressive gynecological tumor usually diagnosed with widespread metastases and ascites. Here, we depicted a single-cell landscape of the OC ecosystem with five...
8 maj 2020 · Ascites is present in more than one third of ovarian cancer patients at initial diagnosis and in almost all cases of relapse. 3, 8, 9 The greater the volume and frequency with which ascites...
Figure 1. ScRNA-seq profiling of the pre- and post-menopausal HGSOC ascites environments (A) Overall survival (OS) of ovarian serous adenocarcinoma between pre- and post-menopausal (50-year-old cutoff value) in the cBioPortal database, and Schematic representation of the experimental strategy.
