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Here we present a simple methodology that allows the isolation of oval cells from rat fetal liver without prior induction of liver damage. The use of oval cell 2 (OC2) and oval cell 3 (OC3) antigens as molecular markers allowed the highly precise characterization of this cell population.
In this article, we review some aspects of the regulation of hepatocyte proliferation as well as the interrelationships between hepatocytes and oval cells in different liver growth processes.
2 lut 2022 · Following studies characterized oval cells as hyperplastic epithelial cells with small cellular size, a high nuclear/plasma ratio and expression of the hepatoblast marker alpha-fetoprotein (AFP). 8-11 Oval cells were considered to be bipotential progenitor cells as they showed the capacity to differentiate into hepatocytes and bile duct cells ...
The canals of Hering are destroyed early in primary biliary cholangitis and may be primary sites of scarring in methotrexate toxicity. Research has indicated the presence of intraorgan stem cells of the liver that can proliferate in disease states, so-called oval cells. [5]
Macroovalocytes are enlarged, oval-shaped erythrocytes (red blood cells). They are not seen in healthy blood, and are most commonly seen in megaloblastic anemia. [1] In most instances, the macroovalocyte morphology is due to megaloblastic erythropoiesis (Vitamin B-12 or folate deficiency) but may be seen with dyserythropoiesis.
1 sty 2003 · Oval cells. Liver regeneration. 1. Introduction. During embryonic development hepatoblasts generate the two hepatic epithelial cell lineages, hepatocytes and biliary cells ( Wilson et al., 1963, Zaret, 2001 ).
These small cells, which eventually become differentiated hepatocytes, are termed oval cells because of their morphology (Shinozuka et al., 1978). Importantly, oval cells are not derived from hepatocytes; instead, they are the offspring of a cell in the canal of Hering (Figure 72.1).
