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For all registered patients at a median follow-up of 54 months (interquartile range: 38–73) from biopsy, 3-year and 5-year event-free survival were 59% (95% confidence interval [CI]: 57–61%) and 54% (95% CI: 52–56%), respectively.
We report survival outcomes and prognostic factors in the full cohort of registered patients. Results: For all registered patients at a median follow-up of 54 months (interquartile range: 38-73) from biopsy, 3-year and 5-year event-free survival were 59% (95% confidence interval [CI]: 57-61%) and 54% (95% CI: 52-56%), respectively.
Although osteosarcoma is a rare disease with an annual incidence of about 1–5 cases per million population, it is the most common primary malignant bone cancer with a low overall survival (OS) rate . The introduction of resection and adjuvant and neoadjuvant chemotherapy lead to 5 year survival rates of more than 60% .
The survival rate of osteosarcoma is closely related to tumour metastasis in that 15–20% of patients were diagnosed with distant metastatic lesions at their first visit . Previous studies have recognized that the lung is the most sensitive site, but the occurrence of abdominal metastasis reveals an unusual pattern in which osteosarcoma is ...
27 paź 2021 · Sarcomas at long bones of lower limb and associated joints improved their 5-year survival rates by only 5.6% (Figure 2 C). From the 1980s to 2010s, chordoma and Ewing sarcoma accomplished the largest survival improvement by 17.0%. Osteosarcoma improved the 5-year survival rate by 9.5%.
27 sty 2021 · After the introduction of chemotherapy, the overall survival (OS) increased to an average of 60% [ 3, 6, 7 ]. Multiple studies conclude more favorable survival probabilities in pediatric patients compared with adolescent and young adults (AYA) or older adults [ 8, 9, 10 ].
Relative 10-year survival rates are around 68% in both children and adolescents as well as in young adults (up to 39 years) and decrease significantly in middle and older adulthood (40-65 years, 40%, 65 years and older, 15%) (Figure 2).
