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Abstract. Oral poliovirus vaccine (OPV) is like no other live virus vaccine used in humans: vaccine strains multiply extensively in the intestinal tract, are widely disseminated in the family and community, and immunize a large proportion of the unvaccinated population.
- Polio vaccination: past, present and future - PubMed
Abstract. Live attenuated oral polio vaccine (OPV) and...
- Polio vaccination: past, present and future - PubMed
Abstract. Live attenuated oral polio vaccine (OPV) and inactivated polio vaccine (IPV) are the tools being used to achieve eradication of wild polio virus. Because OPV can rarely cause paralysis and generate revertant polio strains, IPV will have to replace OPV after eradication of wild polio virus is certified to sustain eradication of all ...
History of polio: Outbreaks and vaccine timeline. Learn about polio epidemics and the development, approval and impact of the polio vaccine. Children and a teacher with polio participate in a class at Saint Marys Hospital.
1 mar 2024 · On 13 November 2020, type 2 novel oral polio vaccine (nOPV2) became the first vaccine to be authorized for use under the WHO Emergency Use Listing (EUL) mechanism. The use of nOPV2 is restricted to outbreak response for type 2 circulating vaccine-derived polioviruses (cVDPV2).
Prior to April 2016, the trivalent oral poliovirus vaccine (tOPV) was the most common vaccine used for routine immunization against polio. tOPV protects against all three serotypes (types 1, 2 and 3).
Although it was the first polio vaccine, it was not to be the last; Albert Bruce Sabin (1906–1993) introduced an oral vaccine in the United States in the 1960s that replaced Salk’s. Although the disease was finally brought under control because of these vaccines, the science behind them fired debate that continues to this day.
23 wrz 2022 · To address the risk of circulating VDPVs, a global collaborative effort over the past decade has enabled the development of novel oral polio vaccine type 2 (nOPV2) that is as immunogenic as the current Sabin strain and so equally effective, while being less likely to revert to neurovirulence than Sabin oral polio vaccines.
