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CLASSIFICATION. USE. DOSE (for cats and dogs unless otherwise noted) Chlorpromazine. Alpha-2 adrenergic antagonist D2 dopaminergic antagonist H1 histaminergic antagonist M1 muscarinic cholinergic antagonist. Antiemetic. 0.2–0.4 mg/kg SC or IM Q 8 H. Cisapride. 5-HT4 serotonergic agonist.
Ondansetron (brand names Zofran®, Zuplenz®) is an antiemetic used off label (extra label) to treat severe nausea and vomiting in dogs and cats. Many drugs are commonly prescribed for off-label use in veterinary medicine.
If your cat is hard to pill, consider the injectable forms of the nausea meds, which are often much easier to give than oral. (Injectable Cerenia does sting most cats, but less so if kept refrigerated.) For ondansetron (not Cerenia), the injectable also needs to be given less often than oral. ONDANSETRON (ZOFRAN) Suggested Oral Ondansetron Dosage
Description: Antiemetic. Other Names for this Medication: Zofran®. Common Dosage Forms: Veterinary: None. Human: Tablets: 4 mg, 8 mg, 16 mg, & 24 mg; Orally disintegrating tablets: 4 mg & 8 mg; Oral Liquid: 4 mg/5 mL (0.8 mg/mL). A compounded topical gel may be available.
Six cats with normal complete blood count, serum biochemistry, and urinalysis received 2 mg oral (mean 0.43 mg/kg), subcutaneous (mean 0.4 mg/kg), and intravenous (mean 0.4 mg/kg) ondansetron in a cross-over manner with a 5-day wash out.
1 mar 2010 · Ondansetron is available as a 2 mg/ml injectable, 4 mg tablets and an oral solution (4 mg per 5 ml). The empirical dosage in cats is 0.5 mg/kg bid. Dolasetron is supplied as an injectable and as 50 mg tablets, which must be reformulated for use in cats. The empirical dosage is 0.6–1.0 mg/kg IV or PO sid.
Ondansetron. 0.1–0.2 mg/kg, PO, q 12–24 h; 0.1–0.15 mg/kg, IV, q 8–12 h. Granisetron. 0.5–1 mg/kg, PO, q 12 h; 0.1–0.15 mg/kg, IV, q 8–12 h. Dolasetron. 0.6–1 mg/kg, IV, q 24 h. Maropitant. For acute vomiting: 2 mg/kg, PO, or 1 mg/kg, SC, q 24 h (acute vomiting); 8 mg/kg/day, PO, for up to 2 days (motion sickness)
