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CLASSIFICATION. USE. DOSE (for cats and dogs unless otherwise noted) Chlorpromazine. Alpha-2 adrenergic antagonist D2 dopaminergic antagonist H1 histaminergic antagonist M1 muscarinic cholinergic antagonist. Antiemetic. 0.2–0.4 mg/kg SC or IM Q 8 H. Cisapride. 5-HT4 serotonergic agonist.
Ondansetron is used to treat and/or prevent severe vomiting in dogs and cats. The FDA (U.S. Food & Drug Administration) has approved this drug for use in humans, but it is not officially approved for use in animals.
Ondansetron (brand names Zofran®, Zuplenz®) is an antiemetic used off label (extra label) to treat severe nausea and vomiting in dogs and cats. Many drugs are commonly prescribed for off-label use in veterinary medicine.
1 mar 2010 · Ondansetron is available as a 2 mg/ml injectable, 4 mg tablets and an oral solution (4 mg per 5 ml). The empirical dosage in cats is 0.5 mg/kg bid. Dolasetron is supplied as an injectable and as 50 mg tablets, which must be reformulated for use in cats. The empirical dosage is 0.6–1.0 mg/kg IV or PO sid.
ondansetron is poorly absorbed in cats (32%, vs. 62% in humans and 10% in dogs), and has a short duration of action in them (approx. 1 to 3 hours, vs. approx. 3 to 6 hours in humans). SubQ duration
In humans, 8 mg of oral or i.v. ondansetron (approximately 0.15 mg/kg) is typically prescribed, and this dose results in a t 1/2 λ that ranges from 3 to 5.5 h, whereas in cats in this study, an average dose of 0.4 mg/kg resulted in a oral and i.v. t 1/2 λ that ranged from of 0.8 to 2.9 h (Roila & Del Favero, 1995).
Ondansetron is most often used in dogs and cats undergoing chemotherapy, to stop the vomiting caused by anti-cancer drugs. It is given to veterinary patients when other drugs have not controlled severe vomiting or when patients are unable to tolerate the more commonly prescribed anti-emetics.
