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CLASSIFICATION. USE. DOSE (for cats and dogs unless otherwise noted) Chlorpromazine. Alpha-2 adrenergic antagonist D2 dopaminergic antagonist H1 histaminergic antagonist M1 muscarinic cholinergic antagonist. Antiemetic. 0.2–0.4 mg/kg SC or IM Q 8 H. Cisapride. 5-HT4 serotonergic agonist.
Ondansetron is used to treat and/or prevent severe vomiting in dogs and cats. The FDA (U.S. Food & Drug Administration) has approved this drug for use in humans, but it is not officially approved for use in animals. The FDA allows veterinarians to prescribe
Ondansetron (brand names Zofran®, Zuplenz®) is an antiemetic used off label (extra label) to treat severe nausea and vomiting in dogs and cats. Many drugs are commonly prescribed for off-label use in veterinary medicine.
1 mar 2010 · Ondansetron is available as a 2 mg/ml injectable, 4 mg tablets and an oral solution (4 mg per 5 ml). The empirical dosage in cats is 0.5 mg/kg bid. Dolasetron is supplied as an injectable and as 50 mg tablets, which must be reformulated for use in cats. The empirical dosage is 0.6–1.0 mg/kg IV or PO sid.
Prediction of ondansetron in cat serum following dosing at 0.5 and 1 mg/kg via i.v., oral and SQ dosing utilizing varied dosing intervals was carried out using nonparametric superposition based on concentration data from single dose studies for each individual cat.
The dosage should be carefully observed, especially in cats and small breed dogs. Following prolonged vomiting, consideration should be given to fluid and electrolyte replacement therapy. In case of vomiting after intake of the oral solution, maintain the usual interval between two administrations before administering the product again.
ondansetron is poorly absorbed in cats (32%, vs. 62% in humans and 10% in dogs), and has a short duration of action in them (approx. 1 to 3 hours, vs. approx. 3 to 6 hours in humans). SubQ duration
