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12 lis 2019 · Oligodendrocytes are fundamental to myelin formation in the developing CNS and critical for myelin regeneration following injury including in the most common demyelinating disease multiple sclerosis (MS) [2, 3].
20 lip 2021 · In this review, we summarize how oligodendrocytes orchestrate myelination, and especially myelin repair after damage, and present novel aspects of oligodendroglial functions.
19 lis 2022 · Injury to myelin-forming oligodendrocytes (OL) in chronic neurological diseases (e.g. multiple sclerosis) ranges from sublethal to lethal, leading to OL dysfunction and myelin pathology, and ...
The sheer numbers of oligodendrocytes in humans are dramatically increased (although the density of oligodendrocytes per mm 3 is remarkably similar between rodents and humans) [140, 176]. Human and rodent OPCs might respond differently to certain factors [ 6 , 168 , 205 , 213 ].
11 wrz 2020 · Oligodendrocytes, the myelin-forming cells of the CNS, are subjected to cell stress and subsequent death in a number of metabolic or inflammatory disorders, among which is multiple sclerosis (MS) [1,2,3,4,5].
23 sie 2022 · Using an integrative analysis of single-cell RNA-seq datasets across disease models of AD and MS, Pandey et al. identified three distinct activation states of oligodendrocytes. Human MS oligodendrocytes share activation genes with mouse models, whereas the human AD response is largely distinct.
10 kwi 2022 · Oligodendrocytes (OLs), the myelinating cells of the CNS , are found in all vertebrates and are fundamental to myelin formation during development and critical for myelin regeneration following injury and demyelinating diseases.
