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The sheer numbers of oligodendrocytes in humans are dramatically increased (although the density of oligodendrocytes per mm 3 is remarkably similar between rodents and humans) [140, 176]. Human and rodent OPCs might respond differently to certain factors [6, 168, 205, 213]. This can be shown best in the case of CXCL1.
11 wrz 2020 · Oligodendrocytes, the myelin-forming cells of the CNS, are subjected to cell stress and subsequent death in a number of metabolic or inflammatory disorders, among which is multiple sclerosis (MS) [1,2,3,4,5].
In photoallergy, an allergic reaction causes redness, scaling, itching, and sometimes blisters and spots that resemble hives. This type of reaction can be caused by aftershave lotions, sunscreens, and sulfonamides.
28 sty 2019 · Investigating human oligodendrogenesis and the interaction of oligodendrocytes with neurons and astrocytes would accelerate our understanding of the mechanisms underlying white matter...
12 lis 2019 · Oligodendrocytes are fundamental to myelin formation in the developing CNS and critical for myelin regeneration following injury including in the most common demyelinating disease multiple sclerosis (MS) [2, 3].
22 paź 2009 · Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are the end product of a cell lineage which has to undergo a complex and precisely timed program of proliferation, migration, differentiation, and myelination to finally produce the insulating sheath of axons.
23 sie 2022 · Using an integrative analysis of single-cell RNA-seq datasets across disease models of AD and MS, Pandey et al. identified three distinct activation states of oligodendrocytes. Human MS oligodendrocytes share activation genes with mouse models, whereas the human AD response is largely distinct.
