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12 lis 2019 · Oligodendrocytes in myelination, demyelination and remyelination. Oligodendrocytes myelinate large diameter axons in the CNS and provide trophic support for the underlying axon. Oligodendrocytes are highly vulnerable and insults such as trauma, immune-mediated attacks or ischaemia can lead to oligodendrocyte death and demyelination.
23 sie 2022 · Using an integrative analysis of single-cell RNA-seq datasets across disease models of AD and MS, Pandey et al. identified three distinct activation states of oligodendrocytes. Human MS oligodendrocytes share activation genes with mouse models, whereas the human AD response is largely distinct.
3 gru 2021 · Genetic diseases causing oligodendrocyte defects can cause dysmyelination (such as in Pelizaeus–Merzbacher disease ) which usually leads to early death.
11 wrz 2020 · Oligodendrocytes, the myelin-forming cells of the CNS, are subjected to cell stress and subsequent death in a number of metabolic or inflammatory disorders, among which is multiple sclerosis (MS) [1, 2, 3, 4, 5].
The sheer numbers of oligodendrocytes in humans are dramatically increased (although the density of oligodendrocytes per mm 3 is remarkably similar between rodents and humans) [140, 176]. Human and rodent OPCs might respond differently to certain factors [6, 168, 205, 213]. This can be shown best in the case of CXCL1.
28 sty 2019 · Investigating human oligodendrogenesis and the interaction of oligodendrocytes with neurons and astrocytes would accelerate our understanding of the mechanisms underlying white matter...
10 kwi 2022 · Oligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS) and myelinate the axons facilitating and boosting the propagation and speed of nerve conduction. In addition, the OLs also provide metabolic support to neurons and enhance their...
