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Learn about the DNA repair mechanism that removes bulky lesions induced by UV light and other mutagens. Find out how NER is divided into two subpathways, global genomic NER and transcription coupled NER, and what diseases are caused by NER deficiencies.
Here I will review the nucleotide excision repair (NER) pathway, a versatile mechanism that removes helix-distorting DNA lesions and structures from the genome. Several other dedicated pathways that have evolved to deal with different classes of lesions or non-canonical forms of DNA will be addressed in other sections in this volume.
23 cze 2014 · Nucleotide excision repair (NER) eliminates structurally diverse DNA lesions by repairing helix-distorting damage throughout the genome as well as transcription-blocking lesions.
Nucleotide excision repair (NER) is a major pathway to deal with bulky adducts induced by various environmental toxins in all cellular organisms. The two sub-pathways of NER, global genome repair (GGR) and transcription-coupled repair (TCR), differ in the damage recognition modes.
At least five major DNA repair pathways—base excision repair (BER), nucleotide excision repair (NER), mismatch repair (MMR), homologous recombination (HR) and non-homologous end joining (NHEJ)—are active throughout different stages of the cell cycle, allowing the cells to repair the DNA damage.
Learn about the versatile DNA repair system that removes bulky and helix-distorting lesions from the DNA strands. Find chapters and articles on NER mechanisms, pathways, diseases, and roles in DNA damage response and neurodegeneration.
9 lip 2021 · Nucleotide excision repair refers to repair of DNA replication lesions or bulky adducts arising from distortions of the DNA structure. 3,200 Mismatch repair refers to adjustment of mismatched...
