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27 paź 2020 · Objective: To explore the physiological functions of the enhancer cluster and elucidate the genomic mechanism underlying Nppa-Nppb coregulation in vivo. Methods and Results: By analyzing epigenetic data we uncovered an enhancer cluster with super enhancer characteristics upstream of Nppb.
8 sty 2021 · Coordinated ventricular expression of Nppa and Nppb is controlled in a competitive manner by a shared super enhancer, which is also required to augment stress-induced expression and to prevent premature hypertrophy.
7 sty 2021 · Nppa encodes ANP (atrial natriuretic peptide), whereas Nppb encodes BNP (B-type natriuretic peptide), both hormones secreted by the heart and involved in cardiac development, cardiorenal homeostasis and also implicated in response to cardiac injury and stress.
Methods. We initially assessed serum inflammatory markers and myocardial injury indicators in septic mice. This involved observing inflammatory cell infiltration in ventricular muscle tissue, assessing cardiac function, and recording electrocardiograms.
2 wrz 2020 · We aimed to examine the associations of BNP and methylation of its coding gene (natriuretic peptide B [NPPB]) with the functional outcome in a large sample of patients with acute ischemic stroke from CATIS (China Antihypertensive Trial in Acute Ischemic Stroke).
Myocardial stretch signal is the key stimulant for BNP synthesis through activation of the proBNP gene, but catecholamines, angiotensin II, endothelin, hypoxia, inflammation, and fibrosis are also factors known to stimulate BNP release, as observed in both animal and human studies.
The Nppa–Nppb gene cluster provides a conceptual framework for understanding gene cluster function and enhancer sharing that likely applies to other loci that harbor clustered genes.
