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31 lip 2023 · The dose is repeatable every 5 minutes until the achievement of relief. If anginal pain persists after three doses, prompt medical attention is required. After administration, the onset of vasodilatory effects occurs within 1 to 3 minutes, with a max effect occurring within 5 minutes.
9 lip 2022 · Nitroglycerin, a fast-acting vasodilator, is commonly used as a first-line agent for angina in the emergency department and to manage chest pain due to acute coronary syndromes. It is also a treatment option for other disease states such as acute heart failure, pulmonary edema, and aortic dissection ….
12 maj 2023 · The goal of this study was to evaluate the safety, the tolerability, the feasibility, the dose-limiting toxicity, and the maximum tolerated dose of NTG patch associated with 5-fluorouracil and radiation therapy. Three sequential doses of NTG were studied: 0.2, 0.4, and 0.6 mg/h (3 patients by dose).
7 lis 2017 · Nitroglycerin has a plasma half-life of approximately one to four minutes; following hepatic and intravascular metabolism, its biologically active metabolites have a half-life of approximately 40 minutes (8,58).
Summary. Nitroglycerin is a nitrate vasodilator used to treat or prevent angina, heart failure, hypertension, and anal fissures. Brand Names. Gonitro, Minitran, Nitro-bid, Nitro-dur, Nitroject, Nitrolingual, Nitromist, Nitrostat, Rectiv, Trinipatch. Generic Name. Nitroglycerin. DrugBank Accession Number. DB00727. Background.
General. Type: vasodilator; stimulates cGMP production causing vascular smooth muscle relaxation. Dosage Forms: SL, IV. Common Trade Names: Nitrolingual, NitroMist, Nitrostat. Adult Dosing. Angina, acute. 0.3 - 0.6mg SL q5min, max: 3 doses within 15 min. IV form: 5 mcg/min IV, increase 5-20 mcg/min q3-5min. Hypertension.
10 cze 2024 · Sublingual nitroglycerin (0.3–0.4 mg every 5 minutes for up to 3 doses) is recommended in patients with NSTE ACS who have continuing ischemic pain; IV nitroglycerin may be used in patients with heart failure, hypertension, or persistent ischemia not relieved with sublingual nitroglycerin and administration of a β-blocker. 1100 Topical or ...
