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31 lip 2023 · Nitroglycerin is a vasodilatory drug used primarily to provide relief from anginal chest pain. It is currently FDA approved for the acute relief of an attack or acute prophylaxis of angina pectoris secondary to coronary artery disease.
12 maj 2023 · The goal of this study was to evaluate the safety, the tolerability, the feasibility, the dose-limiting toxicity, and the maximum tolerated dose of NTG patch associated with 5-fluorouracil and radiation therapy. Three sequential doses of NTG were studied: 0.2, 0.4, and 0.6 mg/h (3 patients by dose).
24 lip 2009 · Mitochondrial aldehyde dehydrogenase-2 (ALDH2) plays an essential role in nitroglycerin (GTN) bioactivation, resulting in formation of NO or a related activator of soluble guanylate cyclase. ALDH2 denitrates GTN to 1,2-glyceryl dinitrate and nitrite but also catalyzes reduction of GTN to NO.
Nitroglycerin | C3H5 (NO3)3 or C3H5N3O9 | CID 4510 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
7 lis 2017 · The mitochondrial isoform of aldehyde dehydrogenase, ALDH-2, was found to be a key enzyme in the biotransformation of nitroglycerin via this pathway as it generates inorganic nitrite (NO 2 −) and 1,2-glyceryl dinitrate from nitroglycerin. There are three proposed mechanisms for the release of the vasoactive molecule via this pathway: nitrogen ...
Summary. Nitroglycerin is a nitrate vasodilator used to treat or prevent angina, heart failure, hypertension, and anal fissures. Brand Names. Gonitro, Minitran, Nitro-bid, Nitro-dur, Nitroject, Nitrolingual, Nitromist, Nitrostat, Rectiv, Trinipatch. Generic Name. Nitroglycerin. DrugBank Accession Number. DB00727. Background.
The pharmacokinetics of nitroglycerin and the formation of its dinitrate metabolites (1,2-glyceryl dinitrate and 1,3-glyceryl dinitrate) were determined in six healthy volunteers after administration of six oral solution doses ranging from 0.4 mg to 13 mg. ANOVA analysis indicated significant differ ….
