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12 maj 2023 · Nitroglycerin (NTG) is a prodrug that has long been used in clinical practice for the treatment of angina pectoris. The biotransformation of NTG and subsequent release of nitric oxide (NO) is responsible for its vasodilatating property.
27 sty 2021 · Multiple clinical studies (Table 2) have demonstrated the efficacy of nitroglycerin (GTN), an organic nitrate, within the treatment of cancer. For example, in one phase II clinical trial, transdermal GTN improved outcomes for patients with advanced non-squamous cell lung cancer [ 226 ].
Highlights. •. Nitroglycerin didn’t improve overall survival of NSCLC patients. •. The toxicity of combining nitroglycerin with standard treatment was mild. •. Increased uptake of HX4 showed negative prognostic significance in NSCLC patients. •. Tumor perfusion after nitroglycerin treatment did not correlate with outcome.
Background: We sought to determine whether the substantial benefits of topical nitroglycerin with first-line, platinum-based, doublet chemotherapy in advanced nonsmall-cell lung cancer (NSCLC) seen in a phase II trial could be corroborated in a rigorous, multicenter, phase III trial.
Nitroglycerin shows promise in lung cancer. Addition of nitroglycerin to vinorel-bine and cisplatin significantly improves overall response and time to progression in patients with inoper-able advanced non-small-cell lung cancer (NSCLC), according to results from a phase II trial.
12 maj 2023 · Nitroglycerin (NTG) is a prodrug that has long been used in clinical practice for the treatment of angina pectoris. The biotransformation of NTG and subsequent release of nitric oxide (NO) is responsible for its vasodilatating property.
11 lis 2021 · BIOMARKERS for Nitroglycerin were identified for four types of cancers through Survival Analysis. The four types of cancers are Bladder cancer, Endometrial cancer, Melanoma and Non-small...
