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Finally, the latest 3-year clinical trial by Storer and colleagues also confirmed the effects of testosterone replacement therapy, using 7.5 g of 1% testosterone gel, on lean body mass in 135 community-dwelling older men over 60 years of age with baseline total testosterone levels of 100–400 ng/dL and free testosterone of <50 pg/mL . In this ...
TRT may result in erythrocytosis in some men, however long-term studies have not reported significant adverse events (e.g. cerebrovascular accident, vascular occlusive events, venous thromboembolisms).
16 kwi 2013 · Older men can be at a higher risk of experiencing adverse events during testosterone therapy than young men for several reasons. Plasma clearance of testosterone is lower in men aged ≥59...
18 lut 2016 · Serum testosterone concentrations decrease as men age, but benefits of raising testosterone levels in older men have not been established. We assigned 790 men 65 years of age or older...
8 paź 2019 · While the effects of testosterone in younger men have been well-described, the effects of testosterone replacement therapy in older men over 60 years of age remain significantly understudied.
While some clinical trials reported an association between testosterone insufficiency in older men and increased risk of death, the exact effects and consequences of testosterone replacement therapy, specifically in older men, remain unclear.
Testosterone therapy produces a number of adverse effects, including worsening of sleep apnea, gynecomastia, polycythemia and elevation of PSA. Efficacy and adverse effects should be assessed frequently throughout the course of therapy. Keywords: aging, testosterone, hypogonadism, physical function. Testosterone physiology in health.
