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27 mar 2023 · Nitrofurantoin was prescribed at a median dosage of 4.1 mg/kg (range 1.9 to 5.6 mg/kg, Tables 1 and S1) orally every 24 hours until otherwise directed, to be given at night after the dog's last urination of the evening.
Each dog's urinary tract infection was associated with a nitrofurantoin-susceptible, multidrug-resistant uropathogen. The median dosage and duration of nitrofurantoin treatment was 4.3 mg/kg by mouth every 8 hours for 14 days.
Nitrofurantoin can be administered PO or parenterally. The dosage for dogs and cats is 4.4 mg/kg, PO, every 8 hours for 4–10 days. Adverse effects are not common at usual dosages, but nausea, vomiting, and diarrhea can develop; CNS disorders have occurred, and polyneuropathy is a serious effect seen in people.
Urinary tract infections (UTIs) are common in small animal practice; it has been reported that up to 27% of dogs will develop infection at some time in their lives. 1 Most UTIs are successfully treated with commonly used drugs, dosages, and administration intervals.
Based on this small study group, nightly nitrofurantoin appears well tolerated and might be efficacious prophylaxis for recurrent urinary tract infections in dogs. Infection with nitrofurantoin-resistant Proteus spp. was a common reason for treatment failure.
Adverse effects include anorexia, emesis, polydipsia, anxiety, aggression, lethargy, hypersalivation, swollen vulvae, estrous behavior, sexual attractiveness, and mammary hyperplasia. Estrogenic effects generally resolve with lowered dosage. Estriol should not be used with other estrogens.
20 gru 2022 · The data presented in this study combined with in vitro sensitivity data from common urine pathogens and the lack of observed adverse effects suggest that nitrofurantoin in a standard dosing regimen could be effective in sporadic bacterial cystitis treatment in dogs.
