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15 wrz 2020 · Survival has improved, but varies widely by GPA for patients with non–small-cell lung, breast, melanoma, GI, and renal cancer with brain metastases from 7-47 months, 3-36 months, 5-34 months, 3-17 months, and 4-35 months, respectively. Conclusion.
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PURPOSEConventional wisdom has rendered patients with brain...
- Journal of Clinical Oncology
Founded in 1964, the American Society of Clinical Oncology,...
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Survival has improved, but varies widely by GPA for patients with non–small-cell lung, breast, melanoma, GI, and renal cancer with brain metastases from 7-47 months, 3-36 months, 5-34 months, 3-17 months, and 4-35 months, respectively. CONCLUSION.
15 wrz 2020 · Median survival varies widely and our ability to estimate survival for patients with brain metastases has improved. The updated GPA (available free at brainmetgpa.com) provides an accurate tool with which to estimate survival, individualize treatment, and stratify clinical trials.
7 lis 2022 · The estimated overall survival median after the diagnosis of brain metastasis was six months (95% CI: 5.5-6.5). Conclusion. We recommend conducting a nationwide study to better understand the incidence in accordance to geographical and gender differences.
12 maj 2022 · Median survival was 0.7 months in the worst prognostic group of the latter score, with a hazard ratio for death of 44 (95% confidence interval (CI), 6–340) compared to the best group. However, many patients with short survival were not assigned to the worst group.
1 lis 2022 · Brain metastases (BM) are associated with dismal prognosis as they cause significant morbidity and affect the quality of life of patients. Management of BM depends on the following factors: age, patient performance, size and the number of lesions, location of the tumor, comorbidities, primary tumor type, and extracranial disease burden.
Recommendations. Surgery is a reasonable option for patients with brain metastases. Patients with large tumors with mass effect are more likely to benefit than those with multiple brain metastases and/or uncontrolled systemic disease. Patients with symptomatic brain metastases should receive local therapy regardless of the systemic therapy used.
