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Two studies documented increased MPV in cancer patients compared to controls [49,50] and one study decreased MPV in cancer patients (pre-operatively) . Results were mixed regarding the prognostic role of MPV in esophageal cancer since low MPV was related to both higher survival , advanced cancer stages , and poor prognosis . 3.4.
Most studies in gastric, breast, endometrium, thyroid, and lung cancer documented an elevated MPV in cancer patients. Data were less clear-cut for esophageal, ovarian, and colon cancer, while reduced MPV was observed in renal cell carcinoma and gallbladder cancer.
6 sty 2021 · These results indicate that decreased MPV reflects the activation of platelets and the spread of inflammation in PC patients. It is likely platelet activation enhances the pro-tumorigenic effects of platelets, which reportedly worsen the prognosis of cancer patients.
Moreover, the authors assessed the prognostic value of MPV to show that low preoperative MPV level is an independent unfavorable prognostic factor in patients after total cancer resection . Reduced MPV values were also observed in patients with cancer of the uterine cervix.
review summarizes the most important studies on the impact of MPV levels on outcome and prognosis in different types of cancer conducted in recent years. MPV levels have a significant impact on the length of progression-free survival (PFS) and overall survival (OS)
7 lis 2020 · In recent studies, altered mean platelet volume (MPV) has been associated with prognosis in different types of cancer. However, the prognostic role of the MPV in head and neck squamous cell cancer (HNSCC) is currently discussed controversially.
27 paź 2020 · MPV level and prognosis of cancer. Thirty-four studies including 37 subsets with 9238 patients were analysed for OS. The pooled HRs of high MPV level was 0.98 (95% CI 0.84 to 1.14; figure 2), indicating no association between MPV level and OS in cancer patients.
