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11 lut 2016 · Here, we describe a simple, step-by-step protocol for the swift isolation of mouse DRG, which can be enzymatically dissociated to produce fully differentiated primary neuronal cultures, or processed for downstream analyses, such as immunohistochemistry or RNA profiling.
• Validate potential biomarkers by analyzing their expression patterns in histology samples and correlating them with clinical data. • Study the progression of disease by measuring and comparing key histological parameters in different stages.
23 sty 2023 · Single-nuclei RNA-seq analysis of mouse DRG. We integrated expression data from 37,384 nuclei from five mouse DRGs (Table 1, Supplementary Data 1).
21 cze 2024 · Abstract. Sensory neurons in the dorsal root ganglion (DRG) and trigeminal ganglion (TG) are specialized to detect and transduce diverse environmental stimuli to the central nervous system.
4 mar 2024 · We used this resource to reveal a remarkable degree of morphological and physiological diversity across the transcriptionally distinct DRG neuron subtypes. This mouse DRG neuron toolkit should enable analyses of the neuronal building blocks of somatosensation.
Dorsal Root Ganglion (Azan) A cross-section of a dorsal root ganglion stained with azan to make it easier to see nerve fibers and connective tissue. Compare this slide with MH 050 Dorsal Root Ganglion (H&E). with large nuclei and prominent, red nucleoli.
The dorsal root ganglion (DRG) houses the cell bodies of primary sensory neurons and projects axons to both the peripheral site of injury and the dorsal horn of the spinal cord. Hence, it is conceivable that the DRG is a major site of nociceptive processing in both adaptive and maladaptive pain states.
