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23 sty 2023 · We generated a transcriptome atlas of mouse, guinea pig, cynomolgus monkey, and human DRGs by implementing a common laboratory workflow and multiple data-integration approaches to generate...
21 cze 2024 · To construct the harmonized DRG and TG cell atlases, we began by first separating neurons and non-neurons from 1,013,779 DRG cells/nuclei across 23 datasets (285,564 human, 34,313 rat, 551,313 mouse, 103,383 cynomolgus macaque, 7430 rhesus macaque, and 31,776 guinea pig) and 576,186 TG cells/nuclei across eight datasets (236,829 human and ...
2 lut 2022 · By focusing on expression profiles for ion channels, G protein–coupled receptors (GPCRs), and other pharmacological targets, we provided a rich map of potential drug targets in the human DRG with direct comparison to mouse sensory neuron transcriptomes.
This review aims to summarize both historical and emerging information about the size and location of human DRG, and highlight advances in the understanding of the neurochemical characteristics of human DRG neurons, in particular nociceptive neurons. Keywords: DRG, satellite cells, immunohistochemistry, nociceptor, MRI. Introduction.
4 mar 2024 · We used this resource to reveal a remarkable degree of morphological and physiological diversity across the transcriptionally distinct DRG neuron subtypes. This mouse DRG neuron toolkit should enable analyses of the neuronal building blocks of somatosensation.
H&E-stained sections of dorsal root ganglia (DRG) were evaluated blindly for histopathological lesions by a board-certified pathologist (A.D.M.); scoring was based on the presence and...
Visium-SPG replaces hematoxylin and eosin (H&E) histology with immunofluorescence staining, enabling us to label and quantify four broad cell types across the DLPFC, including NeuN (neurons), OLIG2 (oligodendrocytes), GFAP (astrocytes), and TMEM119 (microglia) (Fig. 4A and fig. S28).
