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Badanie HRD, umożliwia uzyskanie jednoznacznego wyniku podczas jednorazowego badania, gdyż w przeciwieństwie do klasycznych paneli genowych, test bada charakterystyczne markery uszkodzenia chromosomów (poprzez specjalny algorytm oceniający uszkodzenie genomu – genomic scar score).
4 dni temu · A deep learning tool called DeepHRD, built on io9’s OncoGaze platform, predicted homologous recombination deficiency (HRD) with greater accuracy than FDA-approved standard molecular tests, achieving an area under the curve (AUC) of 0.81, according to a new study published in the Journal of Clinical Oncology. 1 The study focused on breast and ovarian cancers using multiple external cohorts ...
1 lut 2024 · Universal genetic testing is recommended at the time of HGSOC diagnosis with most guidelines suggesting germline genetic testing followed by somatic testing, including HRD, for patients without a gBRCAm.
Homologous recombination deficiency (HRD) is a phenotype that is characterized by the inability of a cell to effectively repair DNA double-strand breaks using the homologous recombination repair (HRR) pathway.
17 maj 2021 · Recent data have drawn attention to the assessment of homologous recombination DNA repair (HRR) as a prognostic and predictive biomarker in HGSOC, leading to increasing debate on the optimal means of defining and evaluating HRD, both genotypically and phenotypically.
4 dni temu · The dual testing platforms used in the study were (1) in-house NGS Pan Cancer panel version.3 and (2) GreenPlan HRD test. A summary of the differences between the two platforms is provided in ...
Key Takeaways. Prior to treatment initiation in advanced ovarian cancer, homologous recombination deficiency (HRD) testing is essential in determining the likely magnitude of benefit of poly...
