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The dramatic decline in smallpox fatalities in response to Jenner's vaccine can be traced in the chart, which shows the number of deaths due to smallpox as a share of all deaths in London from 1629 to 1902.
28 lis 2022 · The strength and longevity of smallpox vaccination campaigns globally, combined with current demographic heterogeneity, have shaped the epidemiological landscape today, revealing substantial geographical variation in orthopoxvirus susceptibility.
30 mar 2023 · The studies suggested that smallpox is 80.7% efficacious to prevent human monkeypox and the immunity provided by prior smallpox vaccination is long-lasting. Moreover, the smallpox vaccination decreases the risk of human monkeypox by 5.2-folds.
The estimated annual number of deaths caused by several vaccine-preventable diseases, based on statistical modeling. Estimates come with wide uncertainties, especially for countries with poor vital registration.
21 gru 2020 · This study presents the complete historical weekly record of smallpox mortality in London over more than 250 years (1664-1930), describes it using spectral analyses, and discusses it in the context of events and interventions that might have influenced infectious disease dynamics.
8 sie 2023 · In the 20 century, prior to eradication, the global death toll was over 300 million. Case fatality rates were approximately 30% overall, although survivors frequently suffered significant morbidity including blindness and skin scarring. The last naturally-occurring case of smallpox was found in Somalia in 1977.
This vaccine, Aventis Pasteur smallpox vaccine (APSV; Sanofi-Aventis, Bridgewater, NJ), was manufactured from 1956 to 1957 and was maintained as a frozen preparation. Similar to the Dryvax studies, undiluted APSV was tested along with 1:5 and 1:10 dilutions to compare vaccination success rate and reactogenicity.
