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7 sty 2021 · Two of the triplets shared 2 mutations at a VAF of 9–19% and 27–39%, whereas the third triplet did not (Fig. 7b). Furthermore, we found a single pre-PGCS mutation at a VAF of 39% in the third...
1 sty 2020 · Boklage (2006) has proposed that it is possible that two different sperm fertilize the two pronuclei in the ovulated oocyte, giving rise to two syngamies, and producing two zygotes of different genotypes inside a single zona pellucida—indistinguishable from any other two-cell embryo.
13 sty 2021 · A new study in Nature Genetics used whole-genome sequencing of monozygotic twins, their parents, partners and offspring to identify and characterize early developmental mutations, as well as the...
10 lip 2024 · This is supported by documented cases of human blastocysts containing two separate groups of ICMs in a single blastocoel (Meintjes et al. 2001; Mio and Maeda 2008; Noli et al. 2015), and even triple ICMs (Lee et al. 2008), leading to monochorionic twin or triplet pregnancies respectively.
Zygosity refers to the genetic makeup of the pregnancy, or the number of zygotes that become fertilized leading to a multiple birth. Twins, in rarer cases triplets, quadruplets (four), quintuplets (five), arising from a single fertilized ovum are termed monozygotic (MZ).
10 gru 2011 · Monozygotic (MZ) twins originate when a single egg is fertilized to form one zygote, which then divides into two embryos. Although they share the same genotype they are not phenotypically identical.
1 lip 2014 · Understanding the origin of monozygotic twinning. Zygosity is the one that reflects the type of conception, i.e., whether twins arise from one or two fertilized eggs (MZ or dizygotic (DZ), respectively), whereas chorionicity refers to the type of placentation.
