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10 lip 2024 · Mouse embryonic stem cells (mESCs) that lacked Jarid2 (Jumonji, AT-rich interactive domain 2), a component of the polycomb repressor complex 2, showed a significant reduction in the level of E-cadherin and other genes controlling cell adhesion.
7 sty 2021 · We first estimated the number of discordant postzygotic mutations in pairs of monozygotic twins (381 twin pairs; 2 triplets) by comparing sequence variation in somatic tissues (1 adipose, 204...
21 cze 2015 · By investigating the chromosomes labeling scheme and possible cell labeling combinations, we discover that monozygotic quadruplets may be two pairs of monozygotic twins where the pairs of twins are slightly different from one another.
13 sty 2021 · A new study in Nature Genetics used whole-genome sequencing of monozygotic twins, their parents, partners and offspring to identify and characterize early developmental mutations, as well as...
10 gru 2011 · Monozygotic twins are considered to be genetically identical, yet can show high discordance in their phenotypes and disease susceptibility. Several studies have emphasized the influence of external factors and the role of epigenetic polymorphism in conferring this variability.
1 sty 2020 · If two genetically distinct populations of cells were formed before repulsion, another distinct cellular differentiation event would have to occur in at least one of the resultant cell populations at the same embryological state in order to produce monozygotic triplets.
gotic triplets in which one zygote splits and another does not in the same cohort of oocytes and under the same ovulatory conditions. Even more intriguing and equally unexplained by the repulsion theory is the occurrence of monozygotic triplets, in which a subse-quent and distinct cellular differentiation event would
