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The gene responsible for this condition is autosomal dominant and can be transmitted by the mother or the father. However, approximately 20% of affected children have inherited a particular gene from their father that is active; a change in the relevant gene increases the risk, albeit to an unknown degree.
7 sty 2021 · Two of the triplets shared 2 mutations at a VAF of 9–19% and 27–39%, whereas the third triplet did not (Fig. 7b). Furthermore, we found a single pre-PGCS mutation at a VAF of 39% in the third...
10 lip 2024 · Splitting of the inner cell mass within a blastocyst leads to monochorionic monozygotic twins; if one embryo splits into two blastocysts, dichorionic monozygotic twins develop.
10 gru 2011 · Monozygotic (MZ) twins originate when a single egg is fertilized to form one zygote, which then divides into two embryos. Although they share the same genotype they are not phenotypically identical.
13 sty 2021 · Looking at 381 monozygotic twin pairs and 2 triplets, the authors first estimated the number of postzygotic mutations present in one twin but not the other.
1 sty 2020 · Monozygotic twinning is one of the commonest major congenital abnormalities with an overall incidence at birth of 1:250. The different aspects of the genetic aetiology of this discordance in monozygotic twins will be discussed in this chapter.
Zygosity refers to the genetic makeup of the pregnancy, or the number of zygotes that become fertilized leading to a multiple birth. Twins, in rarer cases triplets, quadruplets (four), quintuplets (five), arising from a single fertilized ovum are termed monozygotic (MZ).
