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Zygosity refers to the genetic makeup of the pregnancy, or the number of zygotes that become fertilized leading to a multiple birth. Twins, in rarer cases triplets, quadruplets (four), quintuplets (five), arising from a single fertilized ovum are termed monozygotic (MZ).
7 sty 2021 · The fraction of C>T and indel mutations increased with a higher VAF in the proband while the fraction of C>G, CpG>TpG and T>C mutations decreased. The later a mutation occurs during embryonic...
1 lip 2014 · Different number of triplets or differential activation of copy genes have been implicated in the variable expression of diseases such as Steinert's myotonic dystrophy in MZ twins. Still there are few data concerning repeat expansion disorders in twins.
10 lip 2024 · Monozygotic (MZ) twins are believed to arise from the fission of a single fertilized embryo at different stages. Monochorionic MZ twins, who share one chorion, originate from the splitting of the inner cell mass (ICM) within a single blastocyst.
13 sty 2021 · A new study in Nature Genetics used whole-genome sequencing of monozygotic twins, their parents, partners and offspring to identify and characterize early developmental mutations, as well as the...
monozygotic twinning. First, monozygotic twins occur in a remarkably constant frequency among dif-ferent racial groups. Second, the different types of monozygotic twin placentation appear to be related to the timing of zygotic splitting (Baldwin, 1994; Benirschke & Kim, 1973; Chitnis et al., 1999; Corner, 1955; Hall, 2003). Third, the frequency ...
1 sty 2020 · Monozygotic twinning is one of the commonest major congenital abnormalities with an overall incidence at birth of 1:250. The worldwide incidence of monozygotic twinning is constant and the variability of twin births is secondary to the different incidence in dizygotic twinning.
