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5 kwi 2024 · Among RNA–DNA interactions are R-loops and RNA-DNA hybrid G-quadruplexes, as well as RNA-DNA triplexes. It is proposed that RNA-DNA triplexes guide RNA-associated regulatory proteins to specific genomic locations, influencing transcription and epigenetic decision making.
23 gru 2015 · Most recent work has revealed that triple interactions between and within RNA molecules serve critical functions to cellular processes such as splicing, telomerase activity, and protein recoding, an activity that appears to extend beyond viruses.
This review describes the fundamental biochemical and structural features of major‐groove RNA triple helices, the structure and function of naturally occurring major‐groove RNA triple helices, and then discusses methods that could be developed for the global discovery of RNA triple helices.
A major-groove RNA triplex structure is stable in isolation by forming consecutive major-groove base triples such as U·A-U and C(+) ·G-C. Minor-groove RNA triplexes, e.g., A-minor motif triplexes, are found in almost all large structured RNAs.
30 lis 2011 · The results of our survey reveal that multiply hydrogen bonded base triples have a high degree of conservation between comparable ribosomal structures, therefore suggesting significant collective contributions towards the overall folding and stabilization of the RNA molecule.
7 sty 2021 · This analysis was restricted to blood and buccal samples with sampling dates, resulting in 766 individuals from 380 biologically independent monozygotic twin pairs and 2 monozygotic triplets.
17 lis 2016 · The formation of RNA-DNA triplexes was confirmed by an electrophoresis mobility shift assay (EMSA) in vitro using either long RNA transcripts or short RNA oligonucleotides. The potential triplex-forming motif found in noncoding DHFR minor transcripts was a particularly AG-rich sequence, which suggests an antiparallel triplex formation between ...
