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In this paper, we showed that lymphoblastoid cell lines derived from the HL-free triplet had higher MKL1 mRNA and protein levels when compared to the HL affected triplets, while cells derived from the HL treated triplets resembled the healthy controls used in the study.
7 sty 2021 · Two of the triplets shared 2 mutations at a VAF of 9–19% and 27–39%, whereas the third triplet did not (Fig. 7b). Furthermore, we found a single pre-PGCS mutation at a VAF of 39% in the third...
10 lip 2024 · Monozygotic (MZ) twins are believed to arise from the fission of a single fertilized embryo at different stages. Monochorionic MZ twins, who share one chorion, originate from the splitting of the inner cell mass (ICM) within a single blastocyst.
28 wrz 2021 · Here, the authors investigate this in an epigenome-wide association study, showing that monozygotic twinning has a characteristic DNA methylation signature in adult somatic tissues.
1 sty 2020 · In the simplest form, twins may either be monozygotic (i.e., produced from a single zygote) or polyzygotic, namely, dizygotic, trizygotic, etc. (i.e., produced from two, three or more zygotes). Logically, when the number of fetuses is greater than the number of zygotes, a monozygotic component exists.
13 sty 2021 · Looking at 381 monozygotic twin pairs and 2 triplets, the authors first estimated the number of postzygotic mutations present in one twin but not the other.
The PITX2 gene was found as a candidate of monozygotic twinning in a molecular screening of an “experimental twinning” model in chickens . PITX2 encodes a protein that acts as a transcription factor, regulating the expression of genes involved with the formation of the embryonic axis.
