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Monoclonal B-cell lymphocytosis (MBL) is a recently described medical condition that displays biological similarities to the most common subtype of adult leukemia in the Western world, i.e. chronic lymphocytic leukemia (CLL).
21 sty 2010 · Recent studies suggest that more than 4% of the general population over age 40 harbor a population of clonal B cells with the phenotype of either CLL or another B-cell malignancy, a...
23 lip 2015 · Monoclonal B lymphocytosis (MBL) is defined as the presence of a clonal B-cell population in the peripheral blood with fewer than 5 × 10 9 /L B-cells and no other signs of a lymphoproliferative disorder. The majority of cases of MBL have the immunophenotype of chronic lymphocytic leukemia (CLL).
Monoclonal B-cell lymphocytosis (MBL) is a pre-cancerous condition in which there is an abnormal population of lymphocytes called B-cells in the blood. The “fingerprint” of these B-cells is similar to a type of chronic blood cancer known as chronic lymphocytic leukaemia (CLL).
2 Laboratory of B Cell Neoplasia, Division of Molecular Oncology and Lymphoma Unit, ... The percentage of MBL patients free of treatment at 1, 2, and 5 years was 99%, 98%, ... Thomas ME, Mulligan SP. Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. N Engl J Med. 2008 Nov 6;359(19):2065–2066. doi: 10.1056/NEJMc086211. author ...
6 lip 2023 · Monoclonal B cell lymphocytosis (MBL) refers to a monoclonal population of B lymphocytes <5000 cells/microL (<5 x 10 9 /L) in peripheral blood for ≥3 months, without other features of a B cell lymphoproliferative disorder (eg, lymphadenopathy, organomegaly, cytopenias, or extramedullary involvement) [1,2].
10 lis 2021 · The term monoclonal B-cell lymphocytosis (MBL) describes the presence of a clonal B cell population with a count of less than 5 × 10 9 /L and no symptoms or signs of disease. Based on the B cell count, MBL is further classified into 2 distinct subtypes: ‘low-count’ and ‘high-count’ MBL.
