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1 wrz 2012 · In this article we will give a review on the current understanding of eukaryotic Mo-metabolism, involving Mo uptake, Moco biogenesis, Moco transfer and storage and finally its insertion into apo-metalloenzymes. We will focus on eukaryotes because here our understanding of the cell biology of Mo is much more advanced.
12 sie 2009 · Nature has developed two scaffolds holding molybdenum in place, the iron–molybdenum cofactor and pterin-based molybdenum cofactors. Despite the different structures and functions of...
1 sty 2024 · In this chapter, we initially introduce general aspects of molybdenum biochemistry, then, we focus on the functions, deficiencies, and presence of known inhibitors/activators of the five Mo-enzymes, xanthine dehydrogenase, sulfite oxidase, aldehyde oxidase, nitrate reductase, and mARC. 1. Introduction.
19 lip 2024 · Molybdenum (Mo) is an essential element for human life, acting as a cofactor in various enzymes crucial for metabolic homeostasis. This review provides a comprehensive insight into the latest advances in research on molybdenum-containing enzymes and their clinical significance.
1 lip 2006 · Organisms take up Mo in the form of its molybdate anion. It requires specific uptake systems to scavenge molybdate in the presence of competing anions. In bacteria, high-affinity molybdate transporters are described consisting of three protein components and requiring ATP-hydrolysis for operation.
Molybdenum Form and Function For humans, molybdenum functions as a cofactor for at least 4 enzymes: sulfite oxidase, xanthine oxidase, aldehyde oxidase, and mitochondrial amidoxime reducing component. In each case, molybdenum is bound to a complex, multiring organic component called molybdopterin, forming the entity molybde-num cofactor (Figure 1).
The transition element molybdenum (Mo) is of essential importance for (nearly) all biological systems as it is required by enzymes catalyzing diverse key reactions in the global carbon, sulfur and nitrogen metabolism.
