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4 sty 2024 · In this mini-review, we discuss the current state of knowledge concerning the structure of the origin region in bacterial chromosomes and plasmids, recently discovered motifs recognized by replication initiator proteins, and proposed in the literature models describing initial origin opening.
25 lis 2019 · Bacterial chromosomes are folded to compact DNA and facilitate cellular processes. Studying model bacteria has revealed aspects of chromosome folding that are applicable to many species.
A bacterial genomic DNA resides inside cells in a highly condensed and functionally organized form called nucleoid (nucleus-like structure without a nuclear membrane). The Escherichia coli chromosome or nucleoid is composed of the genomic DNA, RNA, and protein.
14 lut 2020 · Presents an integrated view of the expression of bacterial genetic information, genome architecture and function, and bacterial physiology and pathogenesis.
The 3′ → 5′ directed proofreading function of PolIIIε (encoded by dnaQ) contributes to the extremely high fidelity of bacterial DNA replication. The ε subunit comprises a 185-residue N-terminal domain with exonuclease activity, a flexible “Q-linker” sequence, and a smaller CTD that interacts with PolIIIα.
The objective of origin-binding proteins in bacteria, archaea, and eukaryotes is the loading of two helicases onto DNA, which eventually give rise to two DNA replication forks that move in opposite directions from each origin.
In bacteria, the process of DNA replication init iates in a specific DNA region called origin of replication (ori) where multi-protein complexes are positioned and recruits additional initiator proteins to form the Pre-Replicative complex (pre-RC) whose main function is
