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A left directed hydroxyl group (the mirror image) then represented the L-family. Fischer's initial assignment of the D-configuration had a 50:50 chance of being right, but all his subsequent conclusions concerning the relative configurations of various aldoses were soundly based.
We report the discovery of mirror-image DNA-aptamers (Spiegelmer®) that bind and inhibit glucagon. The affinity of the best binding DNA oligonucleotide was remarkably increased (>25-fold) by the introduction of oxygen atoms at selected 2′-positions through deoxyribo- to ribonucleotide exchanges resulting in a mixed DNA/RNA-Spiegelmer (NOX ...
23 sty 2023 · One of their most interesting type of isomer is the mirror-image stereoisomers, a non-superimposable set of two molecules that are mirror image of one another. The existence of these molecules are determined by concept known as chirality. Introduction.
30 lis 2020 · Excessive glucose production by the liver is a key factor in the hyperglycemia observed in type 2 diabetes mellitus (T2DM). Here, we highlight a novel role of liver kinase B1 (Lkb1) in this...
19 lip 2013 · This compound, NOX-G15, is a structured, mirror-image oligonucleotide (a so-called Spiegelmer), conjugated to a 40-kDa polyethylene glycol moiety that can interact with and block glucagon in a manner conceptually similar to a monoclonal antibody.
19 gru 2016 · A chiral molecule and its mirror image are called enantiomers; one is dextrorotatory (D) and the other is levorotatory (L). Ordinary chemical reactions produce L- and D-molecules in equal amounts, referred to as a racemic mixture.
9 sie 2023 · Glucose has 4 chiral centers and 16 stereoisomers, i.e., molecules with the same composition but different spatial configurations. A pair of stereoisomers that are a mirror image of each other but non-superposable are called enantiomers, which rotate the plane of polarization by the same amount but in opposite directions.
