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4 kwi 2020 · As a promising agent, silibinin mediates a wide-range of potent chemopreventive and anti-cancer activities in several frequently diagnosed epithelial malignancies, including skin, colon, prostate and lung.
27 lut 2023 · Small studies suggest benefits of milk thistle in reducing chemo-induced hepatotoxicity in children with acute lymphoblastic leukemia and in non-metastatic breast cancer patients ; and radiation therapy-induced mucositis in those with head and neck cancer .
25 sty 2024 · Claims in relation to cancer are that milk thistle prevents cancer initiation and development, reduces adverse effects of chemotherapy and radiotherapy, and supports the action of some anticancer drugs.
23 gru 2003 · Milk thistle is available in the United States as a dietary supplement. Human clinical trials have investigated milk thistle in hepatitis or cirrhosis, although small studies have been reported in some cancers. Get detailed information on studies of milk thistle in cancer in this clinician summary.
Milk-thistle compounds have also shown direct anticancer activities in preclinical models, including inducing apoptosis of colon cancer cells, causing cancer cell senescence in a mouse model of breast cancer, and blocking angiogenesis in prostate cancer models.
Conclusion: Milk thistle has antioxidant, anti-inflammatory, anticancer, antifungal, immunomodulatory, and other properties. The evidence from human research about the role of milk thistle in oral diseases is limited.
1 paź 2021 · The use of natural products such as polyphenols, may be useful for modulating xenobiotic-metabolizing enzymes and metabolic pathways to induce death in cancer cells. In addition to their chemopreventive properties, many natural products have been shown to be chemosensitizers.
