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13 maj 2019 · Improved understanding of small vessel disease mechanisms is essential to find ways to prevent damage to the brain, to delay worsening or even reverse the damage, or enhance repair to prevent or delay the damaging clinical consequences of the disease.
22 lis 2019 · Given the success in preventing stroke in general, with important reductions in incidence and mortality, are new treatments to target cSVD progression even necessary? That they are is supported by the evidence that many patients with cSVD experience progression with cognitive and functional decline despite conventional stroke risk reduction.
Mitochondrial DNA mutations are a rare cause of adult-onset leukoencephalopathy. Typically patients will present with a multisystem disorder, often including short stature, migraine, sensorineural deafness, cardiac defects and exercise intolerance.
17 sie 2021 · Since the characterization in the late 1990s of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, several other monogenic conditions leading to adult-onset ischemic or hemorrhagic stroke have been described.
27 gru 2022 · Reducing the impact of cerebral small vessel disease (SVD) remains one of the major challenges in stroke medicine. Stroke itself is heterogeneous, with the most common ischemic pathologies being large artery atherosclerosis, cardioembolism, and SVD.
More than 100 heritable disorders can present with abnormal white matter on neuroimaging. While acquired disorders remain a more common cause of leukoencephalopathy in the adult than genetic causes, the clinician must remain aware of features that suggest a possible genetic etiology.
Results. Sixteen women and 15 men (mean age 68 years, not different between sexes) displayed LE, a diffuse hypo-density in the hemispheric white matter in all patients, but which predominated anteriorly (15 patients) more often than posteriorly (2 patients).
