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13 maj 2019 · Most small vessel disease is sporadic, perhaps related to hypertension or other vascular risk factors, but a small proportion is due to rare genetic variants, of which the commonest is cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
22 lis 2019 · Given the success in preventing stroke in general, with important reductions in incidence and mortality, are new treatments to target cSVD progression even necessary? That they are is supported by the evidence that many patients with cSVD experience progression with cognitive and functional decline despite conventional stroke risk reduction.
Juvenile and adult (late) forms of the disease have a milder, more varied phenotype, a slower rate of progression and a significantly longer lifespan (although we have observed a rapid deterioration over a year in one case). Typical features include spasticity, dementia, ataxia, peripheral neuropathy and visual loss.
8 sty 2019 · Leukoencephalopathy with Axonal Spheroids and Pigmented Glia.—Studies (58–61) have shown that these pathologically defined entities are the result of autosomal dominant mutations in the colony-stimulating factor 1 receptor (CSF1R) gene. Both familial and de novo mutations have been described.
27 gru 2022 · Furthermore, CMBs occur in both forms of SVD and are associated with an increased risk of ICH, while recurrent ischemic stroke is common in patients with ICH due to SVD, raising questions as to optimal antithrombotic therapy.
30 sty 2024 · In the beginning stages of progressive white matter disease, the symptoms may be mild. As time passes, however, the symptoms may get worse.
Post-ischemic Leukoencephalopathy after Endovascular Treatment for Acute Ischemic Stroke. Can J Neurol Sci. 2019 May;46 (3):363-365. doi: 10.1017/cjn.2019.30.
