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22 lis 2019 · Given the success in preventing stroke in general, with important reductions in incidence and mortality, are new treatments to target cSVD progression even necessary? That they are is supported by the evidence that many patients with cSVD experience progression with cognitive and functional decline despite conventional stroke risk reduction.
21 lut 2024 · A quarter of ischaemic strokes are lacunar subtype, typically neurologically mild, usually resulting from intrinsic cerebral small vessel pathology, with risk factor profiles and outcome rates differing from other stroke subtypes.
13 maj 2019 · Most small vessel disease is sporadic, perhaps related to hypertension or other vascular risk factors, but a small proportion is due to rare genetic variants, of which the commonest is cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
Patients with a history of immunosuppression should be tested for progressive multifocal leukoencephalopathy by cerebrospinal fluid (CSF) examination for the presence of JC virus. A high index of suspicion should remain for neoplasia, including primary central nervous system (CNS) lymphoma and gliomatosis cerebri.
17 sie 2021 · A small proportion of cerebral small vessel diseases is attributable to monogenic conditions. Since the characterization in the late 1990s of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, several other monogenic conditions leading to adult-onset ischemic or hemorrhagic stroke have been described.
Results. Sixteen women and 15 men (mean age 68 years, not different between sexes) displayed LE, a diffuse hypo-density in the hemispheric white matter in all patients, but which predominated anteriorly (15 patients) more often than posteriorly (2 patients).
27 gru 2022 · They report a high prevalence of imaging features of SVD with moderate-to-severe WMH was 20.5%, 40.5%, and 58.4% in the community, stroke, and dementia groups, respectively. The median prevalence of lacunes was 0.8% and 33.5% in the community and stroke groups.
