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22 lis 2019 · Given the success in preventing stroke in general, with important reductions in incidence and mortality, are new treatments to target cSVD progression even necessary? That they are is supported by the evidence that many patients with cSVD experience progression with cognitive and functional decline despite conventional stroke risk reduction.
13 maj 2019 · Most small vessel disease is sporadic, perhaps related to hypertension or other vascular risk factors, but a small proportion is due to rare genetic variants, of which the commonest is cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.
Patients with a history of immunosuppression should be tested for progressive multifocal leukoencephalopathy by cerebrospinal fluid (CSF) examination for the presence of JC virus. A high index of suspicion should remain for neoplasia, including primary central nervous system (CNS) lymphoma and gliomatosis cerebri.
21 lut 2024 · A quarter of ischaemic strokes are lacunar subtype, typically neurologically mild, usually resulting from intrinsic cerebral small vessel pathology, with risk factor profiles and outcome rates differing from other stroke subtypes.
Large vessel occlusion (LVO) accounts for up to 38% of acute ischaemic stroke and comes with devastating outcomes for patients, families and society in the pre-intervention era.
Contrary to our findings, a prior meta-analysis by Xiong et al 26 showed that patients with ELVO with minor or mild symptoms (NIHSS ≤8) who underwent MT had a significantly better 90-day mRS score at the cost of higher rate of sICH compared with those who received bMM.
Delayed post-ischemic leukoencephalopathy (DPIL) follow-ing successful recanalization of a cerebral artery occlusion is a rare but significant complication that causes aphasia, dementia, and motor impairment [1, 2].
