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15 cze 2023 · PLX3397 (pexidartinib)‐induced microglia depletion mitigates neuroimmune response and reduces cardiac sympathetic activity, leading to the attenuation of cardiac sympathetic remodeling, electrical remodeling, and structural remodeling and the improvement of cardiac function.
2 mar 2021 · These activated microglia release small amounts of ATP, which targets P2Y1 receptors located on astrocytes, leading to glutamate release; subsequently, glutamate acts on neuronal receptors 72.
20 mar 2019 · Evidence suggests that interplay between bone marrow, microglia and immune mediators underlies the development of arterial hypertension, in particular through mechanisms involving cytokines and...
Heart-resident macrophages are critical in cardiovascular diseases, such as chronic heart failure, myocardial infarction, diabetic cardiomyopathy, hypertension, stroke, and atherosclerosis. In general, M1 macrophages are pro-inflammatory whereas M2 macrophages are anti-inflammatory.
14 kwi 2010 · Neuregulin-1 (NRG-1) is a growth and differentiation factor with a well characterized role in neural and cardiac development. Microglia express the NRG1 receptors erbB2, 3, and 4, and NRG1 signaling via the erbB2 receptor stimulated microglial proliferation, chemotaxis, and survival, as well as interleukin-1β release in vitro .
16 lip 2024 · NOD-like receptors (NLRs), particularly NLRP1, NLRP3, and NLRC4 in microglia, are cytoplasmic receptors that oligomerize to form a platform known as inflammasome, a multi-protein complex that finally cleaves pro-IL-1β and pro-IL-18 into their mature forms via caspase-1 (CASP-1) action.
15 cze 2023 · Microglia depletion in the central nervous system attenuates pathological cardiac remodeling after MI by inhibiting neuroimmune response and sympathetic activity.
