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Microglia express several P2Y receptors that are classical G protein-coupled receptors linked to intracellular second messenger systems (Alexander et al. 2021); these receptors regulate a wide range of microglial functions.
1 lut 2024 · Our work has uncovered multiple evolutionary mechanisms underlying cell-surface receptors to facilitate plant adaptations: (i) Expansion of the number of receptors and their recognition...
27 wrz 2024 · To investigate the effect of the specific activation of muscarinic receptors in microglia, we detected the expression of the common seven cytokines and chemokines in LPS-stimulated primary microglia after the administration of pilocarpine.
7 sty 2024 · The colonized microbes in the gut communicate with the brain via the vagus nerve system and immune system, involving microbial metabolites such as short-chain fatty acids (SCFAs), and various transmitters (e.g., polyamines, and amino acids).
12 paź 2021 · Microglia are characteristically derived from erythromyeloid progenitors in the yolk sac in a colony-stimulating factor 1 receptor (CSF1R)-dependent manner and relying on the transcription factors PU.1 and interferon (IFN) regulatory factor 8 (IRF8) signaling (Kierdorf et al., 2013).
5 gru 2022 · The activation of microglia is defined as the classical activation (M1 type) or alternative activation (M2 type). M1 type microglia secrete pro-inflammatory cytokines and neurotoxic mediators to exacerbate neuronal damage, while M2 type microglia promote a repairing anti-inflammatory response.
24 cze 2016 · Here we review data supporting the importance of neurotransmitter receptors on microglia, with a special emphasis on glutamate, γ-aminobutyric acid (GABA), norepinephrine, cannabinoid and acetylcholine receptors.
