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22 paź 2019 · In this review, we explore the neurobiology of microglia in the healthy adult brain and discuss the evidence for microglia influencing the cognitive processes of learning and memory, directly or indirectly, as well as their contribution to the homeostatic maintenance of the brain (Table 1).
- PMC
Microglia originate from yolk sac-primitive macrophages and...
- PMC
Microglial cells are the predominant parenchymal immune cell of the brain. Recent evidence suggests that like peripheral immune cells, microglia patrol the brain in health and disease.
Microglia originate from yolk sac-primitive macrophages and auto-proliferate into adulthood without replacement by bone marrow-derived circulating cells. ... but this effect is less pronounced in adults. However, evidence suggests that microglia play a role in cognition and learning in adulthood and, at a cellular level, may modulate adult ...
16 mar 2021 · All disease-associated microglia show an increased antigen presentation activity (defined as the increased MHCII expression) and elevated expression of monocytes and leukocytes attracting chemokines, especially Ccl12, which is uniformly expressed by tumor-activated microglia but is also found in the microglia isolated from MS patient autopsies ...
In addition, a recent study demonstrated the pivotal role of microglia in neocortex inflammation since they produce and secrete CCL2, a chemokine involved in immune cell recruitment and BBB-microvessel leakage.
12 paź 2021 · As resident macrophages of the central nervous system (CNS), microglia are associated with diverse functions essential to the developing and adult brain during homeostasis and disease.
14 lip 2023 · Microglia states expressing osteopontin (OPN) are observed during demyelination, with a switch to states characterized by upregulation of CD74, CC-chemokine ligand 4 (CCL4) and triggering...
