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Several effects have been reported as related to metformin in PCOS patients including restoring ovulation, reducing weight, reducing circulating androgen levels, reducing the risk of miscarriage and reducing the risk of gestational diabetes mellitus (GDM).
- PMC Free Article
The cumulative incidence of diabetes was lower in the...
- PubMed
The classification of diabetes mellitus and the tests used...
- PMC Free Article
1 gru 2022 · Metformin is typically the first-line treatment for patients with type 2 diabetes; it is not approved for use in prediabetes or PCOS, although it is often prescribed for treatment of these conditions.
11 kwi 2021 · Three CPGs recommended combining LSTs with pharmacological treatments such as metformin to optimize weight loss after 6 months (13,19,20), and 3 recommended bariatric surgery in obese women with PCOS if LST alone failed to achieve sufficient weight loss (14,15,20).
14 lut 2022 · Metformin increases success rates and decreases complication rates when used as an adjunctive medication for ovulation induction during low complexity assisted reproduction treatments and during ovarian stimulation for in vitro fertilization in women with PCOS.
Women with PCOS usually have some of the following symptoms: • Irregular, infrequent or absent periods. • Difficulty becoming pregnant. • Increased testosterone levels resulting in abnormal hair growth, or scalp hair loss, acne, weight gain and insulin resistance.
Significantly more women with PCOS by updated guidelines should be taking metformin than women with PCOS by previous guidelines. Using the old guidelines 12% of patients should be taking metformin which increased to 91% using the new guidelines (p<0.0001).
20 lis 2023 · In 2018, the first evidence-based guideline on assessment and management of PCOS was published, and an updated extended guideline was released in August 2023. These guidelines followed best practice and are endorsed by 39 organizations worldwide, making them the most robust source of evidence to guide clinical practice.
