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15 gru 2021 · Metformin reduces insulin resistance, which constitutes a pathophysiological connection of diabetes with Alzheimer’s disease (AD), but the evidence of metformin on AD development was still...
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- Clinical Pharmacology
Clinical pharmacology is a branch of biomedical science. It...
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27 sty 2022 · Most studies set the outcome as the onset of all-cause cognitive dysfunctions such as dementia and the participants as T2DM patients. A meta-analysis conducted in 2018 have shown that treatment with metformin could effectively lower the risk of subsequent dementia by 34% in elderly people with T2DM (Campbell et al., 2018).
3 lip 2023 · Metformin initiators had a significantly lower risk of dementia compared with patients not receiving anti-diabetes medication. Compared with metformin initiators, diabetes patients not receiving pharmacological treatment had better glycemic profiles at baseline and during follow-up.
3 sie 2022 · Eleven (64.7%) studies reported a reduced risk of dementia associated with metformin use; two (11.8%) suggested metformin increased dementia risk, while four (23.5%) concluded no significant associations.
10 maj 2024 · Current evidence suggests a predominantly positive association between metformin use and a reduced risk of dementia in individuals with diabetes. However, the review shows the complex nature of these outcomes, revealing variations in results in some studies.
25 wrz 2018 · This systematic review found that the available evidence provides some support for metformin having a protective effect against dementia in people who are taking it for the management of diabetes. Meta-analysis of cross-sectional studies showed significantly reduced prevalence of cognitive impairment and dementia amongst users of metformin ...
26 sty 2022 · Most studies set the outcome as the onset of all-cause cognitive dysfunctions such as dementia and the participants as T2DM patients. A meta-analysis conducted in 2018 have shown that treatment with metformin could effectively lower the risk of subsequent dementia by 34% in elderly people with T2DM (Campbell et al., 2018).
