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9 kwi 2024 · Estrogen metabolism is vital to estrogen regulation. Learn how it works and how the DUTCH test can provide insight into hormonal imbalance.
23 sie 2022 · Estrogen is mainly metabolized in the liver through a process called biotransformation. Biotransformation is the process of breaking down estrogens into metabolites that can be excreted from the body. This process is also sometimes referred to as detoxification.
ESTROGEN METABOLISM. Estradiol is readily converted to estrone and both are metabolized, primarily in the liver, to a variety of hydroxylated products [4]. Hydroxylation of the two substrates occurs at carbon 1,2,4,6,7, 11, 14, 15, 16, or 18, with the hydroxyl groups in α or β orientation (Fig. 2).
Abstract. Many enzymes catalyse reactions that have an oestrogen as a substrate and/or a product. The reactions catalysed include aromatisation, oxidation, reduction, sulfonation, desulfonation, hydroxylation and methoxylation.
The ultimate biologic effect of estrogen depends on how it is metabolized. The metabolism of estrogen takes place primarily in the liver through Phase I (hydroxylation) and Phase II (methylation and glucuronidation) pathways, which allow estrogen to be detoxified and excreted from the body.
The ultimate biologic effect of estrogen depends on how it is metabolized. The metabolism of estrogen takes place primarily in the liver through Phase I (hydroxylation) and Phase II (methylation and glucuronidation) pathways, which allow estrogen to be detoxified and excreted from the body.
1 wrz 2022 · Why is estrogen important? Beyond regulating female reproduction, estrogens also control cell growth, gene regulation, bone density, cholesterol production, cardiovascular function, mood & emotions, memory, body temperature, immune function, and aging.
