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23 sie 2021 · Among the expanding list of EDs, 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD, or dioxin) is considered the most toxic chemical produced by humans and has been selected as the “prototypical toxicant” for studying ED transgenerational effects on reproductive health.
This paper provides a critical view of the advances made towards understanding the mechanism of TCDD action. Major topics discussed include the Ah-receptor hypothesis, TCDD as a thyroid hormone agonist, TCDD and vitamin A deficiency, TCDD's effect on receptor regulation, and its effect on intermediary metabolism including related hormonal ...
1 kwi 2023 · Thyroid cancer incidence has been steadily rising since the 1970s and exposure to environmental pollutants, including persistent organic pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other dioxins, has emerged as a potential explanation for this increase.
19 lip 2017 · 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant which elicits hepatotoxicity through activation of the aryl hydrocarbon receptor (AhR).
Carcinogenicity studies with several strains of rats, mice and Syrian hamsters treated with 2,3,7,8-tetrachlorodibenzo- para -dioxin (TCDD) via the oral route (gavage or diet), by intra-peritoneal injection, or by skin application have been reviewed in IARC Monograph Volume 69 (IARC, 1997).
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a halogenated aromatic hydrocarbon (HAH) and widespread environmental pollutant (Poland and Knutson, 1982). TCDD is lipophilic and has a slow rate of metabolism and excretion; thus, it readily concentrates in the food chain (Safe et al., 1991).
2,3,7,8-Tetrachlorodibenzodioksyna, TCDD – organiczny związek chemiczny z grupy dioksyn o bardzo dużej toksyczności. Związek ten został prawdopodobnie wykorzystany do usiłowania otrucia Wiktora Juszczenki jesienią 2004 roku w czasie kampanii prezydenckiej na Ukrainie.
