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5 sty 2022 · Practice Essentials. Multiple endocrine neoplasia type 1 (MEN1) is an endocrine tumor syndrome caused by inactivating mutations of the MEN1 tumor suppressor gene at the 11q13 locus.
5 sty 2022 · MEN1 patients with hyperparathyroidism usually present with mild hypercalcemia, and rarely develop nephrolithiasis. Other manifestations include bone abnormalities and musculoskeletal complaints....
1 wrz 2012 · Conclusions: MEN1 is an autosomal dominant disorder that is due to mutations in the tumor suppressor gene MEN1, which encodes a 610-amino acid protein, menin.
18 lip 2008 · Introduction and Background. Multiple Endocrine Neoplasia type 1 (MEN1) is a rare hereditary endocrine cancer syndrome characterized primarily by tumors of the parathyroid glands (95% of cases), endocrine gastroenteropancreatic (GEP) tract (30-80% of cases), and anterior pituitary (15-90% of cases) (Figure 1) (1).
31 sie 2005 · Multiple endocrine neoplasia type 1 (MEN1) is characterized by varying combinations of more than 20 endocrine and non-endocrine tumors. Endocrine tumors occurring in individuals with MEN1 are shown in Table 2.
11 cze 2019 · Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant hereditary tumor syndrome with a high degree of penetrance, that is caused by inactivating mutations of the tumor suppressor gene MEN1, and is characterized by a predisposition to a multitude of endocrine and nonendocrine tumors (1).
14 cze 2023 · If any of the individual conditions associated with MEN are suspected, especially in patients with a positive family history, it is important to consider a diagnostic workup for any of the other associations.
