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2 wrz 2010 · To the Editor: The Food and Drug Administration (FDA) approved memantine in the United States in October 2003 for the treatment of moderate to severe Alzheimer's disease. 1. The relatively long plasma elimination half‐life of this drug suggests that once‐daily dosing may be comparable with the current twice‐daily practice.
17 lut 2015 · Memantine has a long elimination half-life of approximately 70 hours, which results in little peak-to-trough concentration variations between doses at steady state (after 2 weeks of therapy). 2, 6-8 The soon-to-be-discontinued memantine tablets have been given once daily, which can promote medication adherence and appears to be well tolerated ...
2 wrz 2010 · Because the elimination half-life of memantine is approximately 70 hours, steady state is reached after 2 weeks. As steady state is approached, the difference in peak plasma concentrations between 20 mg once-a-day and 10 mg twice-a-day dosing diminishes (Figure 1).
The terminal elimination half-life of memantine ranges from 60 to 80 hours in humans. 8,12 Following administration of a single oral dose of 10 mg/kg memantine in rats, the elimination half-life was 2.36 ± 0.20 hours.
2 mar 2007 · Memantine is well absorbed from the gastrointestinal tract after oral administration, and its absorption is unaffected by food (Forest Laboratories 2003). It reaches a maximum plasma concentration (Cmax) after a single dose in 3–7 hours, and it has a plasma half-life of about 60–80 hours.
17 lut 2020 · Mean AUC 0-∞ increased by 4%, 60%, and 115% in patients with mild, moderate, and severe renal impairment, respectively. The terminal elimination half-life increased by 18%, 41%, and 95% in patients with mild, moderate, and severe renal impairment, respectively.
12 wrz 2012 · Memantine is excreted in urine mostly as unchanged parent drug with the remainder being metabolised by glucuronidation, hydroxylation and N-oxidation to form NMDA-inactive metabolites. Memantine and its metabolites are primarily eliminated by the kidneys with a terminal elimination half-life of 60–100 hours.
