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All of these findings might indicate that the apparent synergistic antinociceptive effects could depend on the duration of the pain and the pharmacokinetics of the opioid – morphine has a much longer in vivo half life than fentanyl – and the associated development of rapid tolerance .
31 sty 2024 · The elimination half-life is about 60 to 80 hours. Approximately 48% of the drug administered is eliminated unchanged in the urine. The remaining portion is transformed into 3 polar metabolites with minimal NMDAR antagonistic activity.
The terminal elimination half-life of memantine ranges from 60 to 80 hours in humans. 8,12 Following administration of a single oral dose of 10 mg/kg memantine in rats, the elimination half-life was 2.36 ± 0.20 hours.
24 lip 2023 · Estimates of the elimination half-life of amiodarone vary, depending on how the half-life has been measured and the route of amiodarone administration. After long-term oral therapy, amiodarone has a true elimination half-life between 60 and 142 days [ 2,3 ].
17 lut 2020 · Mean AUC 0-∞ increased by 4%, 60%, and 115% in patients with mild, moderate, and severe renal impairment, respectively. The terminal elimination half-life increased by 18%, 41%, and 95% in patients with mild, moderate, and severe renal impairment, respectively.
17 lut 2015 · Memantine has a long elimination half-life of approximately 70 hours, which results in little peak-to-trough concentration variations between doses at steady state (after 2 weeks of therapy). 2, 6 - 8 The soon-to-be-discontinued memantine tablets have been given once daily, which can promote medication adherence and appears to be well tolerated....
14 sty 2021 · Its elimination half-life is multiphasic as follows: in the first three to 10 days after drug withdrawal, amiodarone plasma concentration initially decreases by 50%, followed by a terminal half-life of 26 to 107 days, with a mean of around 53 days. 9 Following repeated intake of amiodarone, administered more frequently than its half-life ...
