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24 lip 2023 · Estimates of the elimination half-life of amiodarone vary, depending on how the half-life has been measured and the route of amiodarone administration. After long-term oral therapy, amiodarone has a true elimination half-life between 60 and 142 days [ 2,3 ].
Memantine (30 mg/kg/day; p.o.) for 2-3 weeks significantly improved the acquisition of the water maze task in APP/PS1 mice without affecting swimming speed. Memantine affected neither locomotor activity nor aggressive behavior in transgenic or wild type mice.
17 lut 2015 · Memantine has a long elimination half-life of approximately 70 hours, which results in little peak-to-trough concentration variations between doses at steady state (after 2 weeks of therapy). 2, 6 - 8 The soon-to-be-discontinued memantine tablets have been given once daily, which can promote medication adherence and appears to be well tolerated....
14 sty 2021 · Its elimination half-life is multiphasic as follows: in the first three to 10 days after drug withdrawal, amiodarone plasma concentration initially decreases by 50%, followed by a terminal half-life of 26 to 107 days, with a mean of around 53 days. 9 Following repeated intake of amiodarone, administered more frequently than its half-life ...
2 wrz 2010 · Because the elimination half-life of memantine is approximately 70 hours, steady state is reached after 2 weeks. As steady state is approached, the difference in peak plasma concentrations between 20 mg once-a-day and 10 mg twice-a-day dosing diminishes (Figure 1).
2 wrz 2010 · RESULTS. In memantine‐naive subjects, the initiation of 20 mg once daily is predicted to result in an initial peak plasma concentration of 19.5 μg/L, twice that which would occur after an initial dose of 10 mg, 5 hours after ingestion. Because the elimination half‐life of memantine is approximately 70 hours, steady state is reached after 2 weeks.
31 sty 2024 · The elimination half-life is about 60 to 80 hours. Approximately 48% of the drug administered is eliminated unchanged in the urine. The remaining portion is transformed into 3 polar metabolites with minimal NMDAR antagonistic activity.
